Duke's defense set the tone early, with Caleb Weaver returning an interception 40 yards to spark the Blue Devils' offensive onslaught. Nate Sheppard scored on a 49-yard rushing touchdown in the first quarter as Duke jumped out to a commanding lead, scoring 10 points in Q1 alone.

The Blue Devils' offense continued to pressure Syracuse throughout the contest, adding 14 points in the second quarter to build a insurmountable advantage. Duke's passing attack, led by Darian Mensah's 268 yards, kept Syracuse's defense on its heels. Mensah connected with receivers including Que'Sean Brown on key third-down conversions.

Syracuse managed only a field goal, scored in the opening quarter, and struggled offensively all afternoon. Despite efforts from rushers like Yasin Willis (63 yards) and receiver Johntay Cook II (84 yards), the Orange were unable to generate sustained momentum.

Duke's defense remained stout throughout, limiting Syracuse's opportunities and forcing critical mistakes. The final score of 38-3 reflects Duke's complete dominance on both sides of the ball in this Week 5 matchup.